IgA nephropathy

Immunoglobulin A nephropathy is considered as the most common primary glomerulonephritis globally. Patients with IgA nephropathy have variable clinical courses and during the past decade much attention has been focused toward factors having prognostic implication. We are working on the recent Oxford classification for IgA nephropathy.
Our published papers on IgA nephropathy
1-Nasri H.Thrombotic microangiopathy in IgA nephropathy. Iran Red Crescent Med J. 2013 Dec;15(12):e10234. doi: 10.5812/ircmj.10234. PMID: 24693377
2-Baradaran A, Nasri H.Significance of Immunostaining Data in IgA Nephropathy Patients; Current Knowledge and New Concepts.Iran J Allergy Asthma Immunol. 2014 Jun;13(3):218-219.PMID:24659127
3-Nasri H, Sajjadieh S, Mardani S, Momeni A, Merikhi A, Madihi Y, Ghiessari A, Emami Naieni A.Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropathy.J Nephropathol. 2013 Jul;2(3):190-5. PMID:24475448
4-Rafieian-Kopaei M, Baradaran A, Nasri H.Significance of extracapillary proliferation in IgA-nephropathy patients with regard to clinical and histopathological variables.Hippokratia. 2013 Jul;17(3):258-61.PMID:24470738
5-Nasri H. Letter to the article: association of C1q deposition with renal outcomes in IgA nephropathy Clin Nephrol. 2013; 80: 98-104.Clin Nephrol. 2014 Mar;81(3):228-9. PMID:24424086
6-Nasri H.IgA nephropathy and significance of immunostaining data.Iran J Immunol. 2013 Dec;10(4):267-9. PMID:24375068
7-Baradaran A, Nasri H.Comment on: Clinical significance of IgG deposition in the glomerular mesangial area in patients with IgA nephropathy.Clin Exp Nephrol. 2014 Feb;18(1):176-7.
8-Baradaran A, Nasri H.Rare association of cutaneous vasculitis, IgA nephropathy and antiphospholipid antibody syndrome with tuberculous lymphadenitis.Clinics (Sao Paulo). 2013 Jul;68(7):1072. PMID:23917677
9-Rafieian-Kopaei M, Nasri H, Alizadeh F, Ataei B, Baradaran A.Immunoglobulin A Nephropathy and Malaria falciparum Infection; a Rare Association.Iran J Public Health. 2013 May 1;42(5):529-33. PMID:23802112
10-Nasri H.Comment on: clinical, histopathological and immunofluorescent findings of IgA nephropathy. Iran J Immunol. 2012 Dec;9(4):266-7; author reply 267.
11-Nasri H, Mortazavi M, Ghorbani A, Shahbazian H, Kheiri S, Baradaran A, et al. Oxford-MEST classification in IgA nephropathy patients: A report from Iran.J Nephropathol. 2012 Apr;1(1):31-42. PMID:24475384
12-Nasri H, Ardalan MR. Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients. J Ren Inj Prev 2012; 1(1): 27-30.
13-Mubarak M. Oxford classification of IgA nephropathy: Broadening the scope of the classification .J Nephropathol. 2012; 1(1):13-6.
14-Baradaran A. Comment on: Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients. J Ren Inj Prev. 2012; 1:9-10.
15-Baradaran A. R: IgG deposition in IgA nephropathy patients. J Ren Inj Prev.2013; 2:39-40.
16-Nasri H, Ardalan MR. Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients. J Ren Inj Prev 2012; 1(1): 27-30.
17-Nasri H, Mubarak M. Significance of vasculopathy in IgA nephropathy patients with regard to Oxford classification and immunostaining findings: a single center experience. J Ren Inj Prev 2013; 2(2): 41-45.
18-Baradaran A. Renal vascular lesions in IgA nephropathy. J Ren Inj Prev. 2013; 2(2): 37-38.

Renal Tubular Cell protection

Baradaran A, Rafieian‑Kopaei M. Re: Protective role of Silymarin and deferoxamine against iron dextran ‑ Induced renal iron deposition in male rats. Int J Prev Med 2014;5:245-6.
Nasri H. Renoprotective effects of garlic. J Ren Inj Prev  2012.
Ardalan MR, Nasri H, Rafieian‑Kopaei M. Comment on: Protective role of recombinant human erythropoietin in kidney and lung injury following renal bilateral ischemia‑reperfusion in rat model. Int J Prev Med 2013;4:1226-7.
Rafieian‑Kopaei M, Nasri H. Comment on: Is the renoprotective effect of erythropoietin in chronic kidney disease a myth? J Formos Med Assoc 2013.
Baradaran A, Rafieian‑Kopaei M. Re: Protective role of Silymarin and deferoxamine against iron dextran ‑ Induced renal iron deposition in male rats. Int J Prev Med 2014;5:245-6.
Rafieian-Kopaei M, Find all citations by this author (default).
Nasri H.  The Ameliorative Effect of Zingiber officinale in Diabetic Nephropathy. Iranian Red Crescent Medical Journal[2014, 16(5).
Nasri, Hamid, Mehdi Nematbakhsh, and Mahmoud Rafieian-Kopaei. "Ethanolic Extract of Garlic for Attenuation of Gentamicin-induced Nephrotoxicity in Wistar Rats." Iranian journal of kidney diseases 7.5 (2013): 376-382.
Nasri H, Tavakoli M, Ahmadi A, Baradaran A, Nematbakhsh M, Rafieian-Kopaei M. Ameliorative effect of melatonin against contrast media induced renal tubular cell injury. Pak J Med Sci 2014;30(2):261-265.
Baradaran, A., et al. "Antioxidant activity and preventive effect of aqueous leaf extract of Aloe Vera on gentamicin-induced nephrotoxicity in male Wistar rats." La Clinica terapeutica 165.1 (2014): 7.
Nasri, Hamid, et al. "Bright Renoprotective Properties of Metformin Beyond Blood Glucose Regulatory Effects." Iranian Journal of Kidney Diseases 7.6 (2013).
Rafieian-Kopaie, M., and H. Nasri. "R: recombinant human erythropoietin reduces rhabdomyolysis-induced acute renal failure in rats." Injury 44.11 (2013): 1662.
Rafieian-Kopaei, M., and H. Nasri. "Re: Erythropoietin Ameliorates Oxidative Stress and Tissue Injury following Renal Ischemia/Reperfusion in Rat Kidney and Lung." Medical principles and practice (2014): 95.
Rafieian-Kopaei, Mahmoud, Shamin Ghobadi, and Hamid Nasri. "The Protective Effect of Garlic Extract on Diabetic Nephropathy. Journal of Isfahan Medical School 31.248 (2013).
Nasri, Hamid. "Protective effects of subchronic caffeine administration on cisplatin induced urogenital toxicity in male mice. Indian journal of experimental biology 51.5 (2013): 406.
Nasri, H. "Reply: Oxytocin ameliorates cisplatin-induced nephrotoxicity in Wistar rats." Annals of Saudi medicine 33.5 (2012): 510-510.
NASRI, Hamid, and Mahmoud RAFIEIAN-KOPAEI. "Tubular Kidney Protection by Antioxidants. Iranian Journal of Public Health 42.10 (2013): 1194-1196.
Nasri, H. "The protective effect of recombinant human erythropoietin against cisplatin-induced renal and hepatic dysfunctions in Wistar rats. Human & experimental toxicology (2014).
Nasri, H. "Ameliorative effects of metformin on renal histologic and biochemical alterations of gentamicin-induced renal toxicity in Wistar rats." Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences 18.7 (2013): 628-628.

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Friday, 18 January 2019 01:12

The theme of World Hypertension Day 2014: Know your Blood Pressure

Firstly World Hypertension Day inaugurated in May 2005 and has become an annual event ever since. The aim of the World Hypertension Day is to promote public alertness of high blood pressure and to promote citizens of all countries to prevent and control this silent killer, the modern epidemic.World Hypertension Day was initiated firstly by the World Hypertension League.High blood pressure (hypertension) is considered as the silent killer since it has no apparent symptoms. Investigations show that the disease involves more than 1.5 billion people global, and around seven million people die every year from hypertension. 

Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD)

The definition of CKD-MBD is different than the previously recognized as "renal osteodystrophy", and it refers to a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following:
•Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D metabolism.
•Abnormalities in bone turnover, mineralization, volume, linear growth, or strenght.
•Vascular or other soft-tissue calcification.
The term "renal osteodystrophy" is now limited to an alteration of bone morphology in patients with CKD, and it is one measure of the skeletal component of the systemic disorder of CKD-MBD that is quantifiable by histomorphometry of bone biopsy.


World Kidney Day 2014:chronic kidney disease and aging

World Kidney Day (WKD) is a joint initiative of the International Society of Nephrology (ISN) and the International Federation of Kidney Foundations (IFKF).Seven years on from the first campaign, World Kidney Day (WKD) has turned into a global phenomenon. On March 13, 2014, medical professionals, government officials, the general public, celebrities and patients will take action locally.
Implication for health policy/practice/research/medical education
In 2014 World Kidney Day (WKD) will focus on chronic kidney disease and aging.The mission of WKD is to raise awareness so that everyone cares for their kidneys and, if appropriate, check to assess if they are at risk for kidney disease. Prevention of kidney disease, early detection, and subsequent kidney protection are critical aims for World Kidney Day.
Our research group is working on the below projects
1-Oxford classification in Iranian IgA nephropathy patients [Renal pathology unite of Dr. Baradaranlaboratory, Isfahan, Iran].
2- Significance of C4d deposits in IgA nephropathy [Renal pathology unite of Dr. Baradaran laboratory, Isfahan, Iran].
3-Renal tubular cell protection by herbal anti-oxidants [Medical Plants Research Center; Shahrekord University of Medical Sciences, Shahrekord, Iran]
4-R229Q Polymorphism of NPHS2 Gene in Patients with Late-Onset Steroid-Resistance Nephrotic Syndrome [Chronic Kidney Disease Research Center; Tabriz University of Medical Sciences,Tabriz, Iran]

Recently Published Papers
Baradaran A. Antiphospholipid syndrome-associated nephropathy; a nephropathy needs classification. J Nephropharmacol. 2012; 1(1):7-9.
Implication for health policy/practice/research/medical education
A suggested classification for antiphospholipid syndrome-associated nephropathy, should be simple and practical. However, the suggestion of a new classification for antiphospholipid syndrome-associated nephropathy will involve a magnificent amount of work and will necessitate a working group, hence, more studies on this topic is suggested.

Nasri H. Antiphospholipid syndrome-associated nephropathy: Current concepts . J Ren Inj Prev 2013; 2(1): 1-2.
Implication for health policy/practice/research/medical education
Renal pathologists and nephrologists should be aware of the morphologic characteristics of APS-nephropathy when they reviewbiopsies of lupus nephropathy patients, especially those with positive antiphospholipid antibodies.

Mubarak M, Nasri H.What nephrolopathologists needto know about antiphospholipid syndrome-associated nephropathy: Is it time for formulating a classification for renal morphologic lesions? J Nephropathology. 2014; 3(1): 4-8.
Implication for health policy/practice/research/medical education
There is sufficient epidemiological, clinical and histopathological evidence to show that antiphospholipid syndrome-associated nephropathy is a distinctive lesion caused by antiphospholipid antibodies in patients with different forms of antiphospholipid syndrome. It is now time to devise a classification for an accurate diagnosis and prognostication of the disease.